Pentosan Polysulphate
Why has my veterinarian prescribed this medicine?
Pentosan polysulphate helps cartilage to repair. It binds to damaged cartilage and stimulates production of new cartilage. It is used for the treatment of arthritis in dogs.
How do I give this medication?
- Your veterinarian will administer this medication by injection to your pet. The medication may be injected directly into the joint.
- Your pet will require a course of treatment as advised by your veterinarian.
Potential side effects
- Your veterinarian may need to monitor your pet's blood to check kidney and liver function.
- Although a drug has potential side effects, it does not mean that there is necessarily a high risk of any of these occurring.
- Pentosan polysulphate may cause spontaneous bleeding (e.g. bruising). Notify your veterinarian if side effects appear.
- Other side effects may occur, if you notice anything unusual, contact your veterinarian.
Possible drug interactions
- Make sure to tell your veterinarian what other medication you are giving to your pet.
- Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
- Drugs may interact such that they can cause an increased or decreased effect or side effects. Although drug interactions may occur, it does not mean that there is necessarily a high risk of any of these occurring. The risk of serious drug interactions is low and should be kept in perspective.
- Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Created on Aug 1, 2015.
